Compliance & Safety Protocol
FOR RESEARCH PURPOSES ONLY. NOT FOR HUMAN CONSUMPTION.
TB-500 (Thymosin Beta-4 Fragment) is a synthetic 43-amino acid peptide representing the active region of the naturally occurring Thymosin Beta-4 protein. With the molecular formula C₂₁₂H₃₅₀N₅₆O₇₈S and a molecular weight of 4963.5 g/mol (CAS: 77591-33-4), TB-500 is the research designation for the peptide fragment containing the primary bioactive sequence of the parent protein.
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH| CAS Number | 885340-08-9 |
| Molecular Formula | C38H68N10O14 |
| Molecular Weight | 868.99 g/mol |
| Purity | ≥99.0% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | −20°C · Lyophilized |
| Shipping | Insulated packaging |
Malinda et al. (2004) examined the actin-binding properties of thymosin beta-4 and its effects on keratinocyte migration in vitro (PMID: 15283699).
PMID: 15283699VERIFY PMIDSosne et al. (2009) investigated TB-4 fragment's effects on corneal epithelial cell migration and integrin expression in cell culture models (PMID: 19189658).
PMID: 19189658VERIFY PMIDHuff et al. (2009) characterized the structure-function relationship of the actin-binding domain within thymosin beta-4 (PMID: 19549937).
PMID: 19549937VERIFY PMIDTB-500 binds to monomeric G-actin, regulating actin polymerization and cytoskeletal dynamics in cell culture models (PMID: 15283699).
Published studies demonstrate effects on cell motility through interactions with integrin receptors and focal adhesion dynamics (PMID: 19189658).
Research Use Only
All compounds are sold strictly for laboratory research use. Not for human or animal consumption. These products are not drugs, supplements, or food. Statements have not been evaluated by the FDA. Must be 21+ to purchase. This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.
